Covid-19: Booster dose reduces infections and severe illness in over 60s, Israeli study reports

SUMMARY Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to direct allele-specific expression. Despite their critical roles in embryonic development, how universal regulators coordinate these specific tasks from single locus chromosome-scale remains understudied. Here, we systematically disrupted multiple essential pathways within polymorphic F1 zygotes examine postimplantation effects on canonical non-canonical genomic as well inactivation. We find that DNA methylation Polycomb group repressors are both indispensable for autosomal imprinting, albeit at distinct gene sets. Moreover, the extraembryonic ectoderm relies a broader spectrum of unique mechanisms, including targeting maternal endogenous retrovirus (ERV) driven promoters by G9a. further utilize our data identify dependent independent clusters imprinted chromosome, which appears reflect domains Xist-mediated suppression. Our has allowed us assemble comprehensive inventory utilized eutherian mammals maintain parent-specific an expanded view placental lineage comprises pathways.